Pharmacogenetic Testing

 

Pharmacogenetic (PGx) testing allows clinicians to better understand how their patients will respond to certain medications.

With PGx testing, it’s possible to tailor medication plans to a patient’s specific genetic makeup. This can lead to:

• Reduced medical costs for patients and providers
   
• Safer medication plans
   
• More efficient drug efficacy
   
   

BENEFITS OF PHARMACOGENETIC TESTING

Identify which drug may be most effective before treatment starts PGx testing can help clinicians choose the most effective drug for each patient, minimize the risk of adverse reactions, and reduce hospitalizations.

Reduce the risk of adverse events related to certain drugs PGx testing can assess a patient’s risk for adverse drug reactions before they take the medication which can improve patient safety and minimize costs for healthcare facilities

 Adjust and optimize the dose of current medications PGx testing can help clinicians predict the appropriate dose of medication for their patient. This allows them to create more personalized medication plans to maximize efficacy and reduce pharmacy costs.

 Improved Patient Care PGx test results become part of a patient’s medical record, allowing physicians to make more informed decisions when prescribing medications for future medical issues.
 

ADVERSE DRUG REACTION (ADR) STATS*

• ADRs are a leading cause of morbidity and mortality in healthcare, causing approximately 100,00 deaths annually.
   
• More than 2 million serious ADRs occur every year.
   
• Nursing homes experience approximately 350,000 ADRs per year.

WHAT TESTING CAN TELL US

PGx testing can reveal if a person is a fast, normal, or

slow metabolizer. A person’s metabolism changes the

way their body responds to medication, including:

• Toxicity

Excessive amounts of the drug accumulate in the bloodstream, resulting in ADRs.

• Lack of Efficency

The bloodstream cannot absorb enough of the drug to achieve a therapeutic effect..

• Hypersensitivity

Normal amounts of the drug enter the bloodstream, but even this is enough to trigger severe reactions in people with hypersensitivity to the medication.

DRUGS INFLUENCED BY GENETIC VARIATION

• Cardiovascular ACE Inhibitors, Antiarrhythmics, Anticoagulants, Antiplatelets, Beta Blockers, Statins
   
• Gastroenterology Proton-Pump Inhibitors
   
• Immunology Calcineurin Inhibitors, Immunosuppresants
   
• Infectious Disease Antivirals, Antibiotics, Antimalarials, Antifungals
   
• Neurology Anticonvulsants
   
• Oncology 5-HT3 Antagonists, Antineoplastic Agents, Estrogen Modulators, Platinum Compounds, Purine Analogs, Pyrimidine Analogs
   
• Pain Management Nonsteroidal Antinflammatory Drugs (NSAIDs), Opioids
   
• Psychiatry Antipsychotics, Benzodiazepines, Selective Serotonin Reuptake Inhibitors (SSRIs), Tricyclic Antidepressants

OUR PANEL OFFERINGS

Two panels available with a physician’s order:

• PGx Focus Panel: Includes genes associated with drug metabolism with high-level evidence and clinically actionable guidelines.
   
• PGx Comprehensive Panel: Includes genes associated with drug metabolism with highlevel evidence and clinically actionable guidelines, in addition to genes with PharmGKB evidence of 2 or higher.

TEST SPECIFICATIONS